Lab Testing


Kaizen Medical offers a broad range of comprehensive and innovative laboratory tests. Testing may be performed to assess existing health issues, possible allergies, general nutritional status, cardiovascular health, digestive health, hormone levels, or to evaluate patient response to certain treatments.

Testing varies significantly from patient to patient, and most tests can be customized to the individual’s personal health needs. Some of the most common tests performed at Kaizen Medical are described in the categories, below.

Hormonal / Endocrinology

Bone Resorption Assay
The Bone Resorption Assay detects biochemical markers which reflect present remodeling activity. The relatively low cost of this assay makes it a cost-effective tool to routinely monitor bone resorption rates and the effectiveness of therapy. Repeated measurements every six to twelve weeks will monitor the effectiveness of your therapeutic interventions and allow timely adjustments.

Complete Estradiol – Progesterone Profile
A salivary test that evaluates the balance between Estradiol and Progesterone over 31 days. This provides clues about menstrual irregularities, infertility, endometriosis, and possible risk of breast cancer and osteoporosis. Once a hormone imbalance has been uncovered, nutritional or bio-identical hormone therapy can be instituted.

Four Point Cortisol Curve Test
A salivary test that assesses the patient’s adrenal function by measuring cortisol levels. Imbalances of cortisol have been associated with ailments such as obesity and difficulty in losing weight, menstrual disorders, immune deficiency and increased risk of cardiovascular disease.

Estrogen Metabolism Ratio Test
The Estrogen Metabolism Ratio looks at how estrogens are broken down by the body. Two of the metabolites of estrogen are 16-alpha-hydroxyestrone (16OHE1) and 2-hydroxyestrone (2OHE1). A proper balance between these two metabolites is important to maintaining good health. 16-alpha-hydroxyestrone (16OHE1) is a more potent estrogen and may therefore promote growth of hormone dependent cancers like breast cancer. Conversely, there is some evidence that the weaker major urinary metabolite of estrogen, 2-hydroxyestrone (2OHE1), alpha-hydroxyestrone may give an indication of breast cancer risk. Studies suggest that an Estrogen Metabolism Ratio (EMR) of greater than 2.0 is associated with decreased breast cancer risk in both pre- and post-menopausal women.

Estronex Profile
The Estronex Profile measures six important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers.

Female Panel
The following five hormones make up the Female Panel: Estradiol (E2), Progesterone (Pg), Testosterone (T), Cortisol (C), and DHEA-S. Interactions between these hormones are fundamental to health and, as a consequence, imbalances may negatively impact health.

Insulin-Like Growth Factor Type 1 (IGF-1) Profile
The Insulin-Like Growth Factor Type 1 (IGF-1) test measures serum levels of IGF-1 (also called Somatomedin C), an anabolic hormone produced in the liver and essential for maintenance of muscle tissue. Serum levels of IGF-1 vary depending on age, sex, growth hormone secretion, liver function, and nutritional status. Levels below normal are associated with chronic stress and fibromyalgia.

Male Panel
The following four hormones make up the Male Panel: Estradiol (E2), Testosterone (T), Cortisol (C), and DHEA-S. Interactions between these hormones are fundamental to health and, as a consequence, imbalances may negatively impact health.

Complete Thyroid Profile
The Comprehensive Thyroid Assessment provides a thorough analysis of thyroid hormone metabolism. It includes central thyroid gland regulation and activity, thyroid production and secretion, peripheral thyroid conversion, and thyroid autoimmunity. This test allows the physician to pinpoint common imbalances that underlie a broad spectrum of chronic illness. Conditions and symptoms associated with hypothyroidism may include: cardiovascular disease, weight gain, fatigue, skin problems, hair thinning, muscle cramps, depression, headaches, or constipation. Conditions and symptoms associated with hyperthyroidism may include: weight loss, increased appetite, nervousness, restlessness, heat intolerance, increased sweating, fatigue, frequent bowel movements, menstrual irregularities in women, and goiter.

Immunology / Food Allergy

Allergy Blood Spot Testing (IgG / IgE)
Two of the antibodies involved in allergic reactions are immunoglobulin E (IgE) and immunoglobulin G (IgG). IgE production occurs right after ingestion or inhalation of an allergen and is referred to as a Type I immediate hypersensitivity reaction. IgG antibodies are produced for several hours or days after exposure to an allergen and are called Type III delayed hypersensitivity reactions. This test assesses sensitivities to 96 of the most common food and environmental allergens, and can be customized to include selected allergens and/or align with a vegetarian diet.

Celiac Profile
The Celiac Profile measures three different types of antibodies in a dried blood spot sample: anti-tissue transglutaminase IgA antibodies, anti-gliadin IgA antibodies and anti-gliadin IgG antibodies. Diagnostic tests for celiac disease must be performed while patient is consuming gluten. Long-term adherence to a gluten-free diet means antibodies to gluten are no longer present and cannot be measured.

Nutritional

Amino Acids 40 Plasma Profile
Amino acids, known as the “building blocks” of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function including the formation of ligaments, tendons, bones, and antibodies, as well as regulation of enzymes and blood transport proteins. Twenty different amino acids are used to synthesize proteins. The human body can synthesize all of the amino acids necessary to build proteins except for ten called the “essential amino acids”. These ten must be included in the diet or supplemented to be in adequate supplies. Failure to obtain enough of even 1 of the 10 essential amino acids has serious health implications and can result in degradation of the body’s proteins. Muscle and other protein structures may be dismantled to obtain the one amino acid that is needed. In addition to pinpointing problems in amino acid absorption and determining essential amino acid imbalances, the Amino Acid 40 Plasma Profile includes evaluation of limiting, branched chain, and essential and non-essential amino acids. It also identifies several functional categories, such as neuroendocrine, vascular, collagen status and detoxification, along with five calculated ratios, and identifies vitamin and mineral insufficiencies.

Fatty Acids Profile
This test assesses blood levels of fatty acids in the body. Improper fatty acid intake affects the balance of anti- and pro-inflammatory eicosanoids, increasing health risks. Among the top five drugs prescribed last year, statins have been shown to unfavorably alter this inflammatory balance. Since inflammation has now been shown to be integral to so many disease processes, nutrients which counteract inflammation can have profound health benefits.

Hair Element Analysis
Hair Element Analysis is used to determine whether a person has had excessive exposure to toxic elements such as lead, mercury or arsenic – the heavy metals that are known to cause serious health problems. Toxic elements concentrate in soft tissue rather than blood or urine, so Hair Element Analysis is uniquely suited for measuring toxic elements. Hair Element Analysis also provides information on the absorption and assimilation of nutritionally important essential elements (e.g. iron, copper), making it useful for assessing nutrient deficiencies and imbalances as well.

NutrEval® Test
In this test, the Amino Acids are measured either in blood plasma, or in a convenient first-morning urine collection. Unlike any other nutritional assessments, NutrEval FMV® provides a framework of core nutrients in the following key areas: Amino Acids, Antioxidants, B Vitamins, Digestive Support, Essential Fatty Acids, and Minerals. Amino acids are integral to healthy body chemistry. They serve as the body’s basic building blocks and are responsible for the production of bone and muscle. Antioxidants are essential for the body’s ability to protect against free radicals, and for healthy function of the neurological, endocrine, and immune systems. Antioxidants are essential for the body’s ability to protect against free radicals, and for healthy function of the neurological, endocrine, and immune systems. Lastly, minerals in our body serve two functions: one being that they are the building blocks, second being that they are regulators of our body’s processes. Once identified, imbalances can be corrected, helping to prevent many chronic illnesses before they can cause severe and lasting damage.

Gastrointestinal

Anti-Candida Antibody Test
This test evaluates blood for the immune response to Candida albicans. Test results can reveal important information about bacterial and yeast overgrowth underlying gastrointestinal symptoms, chronic fatigue, mood shifts and weakened immune function.

Comprehensive Digestive Stool Analysis
This test evaluates digestion, absorption, gut flora, and the colonic environment, and evaluates for parasites using microscopic examination and EIA testing. The profile is indicated for all chronic GI problems, for acute bowel pattern changes, and for many systemic diseases and provides a sensitivity panel for treating pathogenic flora. In addition to identifying general dysfunction, this assay provides direct measures to pinpoint the diagnosis and treatment of patients with many digestive conditions such as Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD).

Comprehensive Parasitology Profile
The Comprehensive Parasitology Profile is a thorough analysis to detect the presence of intestinal parasites, as well as beneficial intestinal microflora, imbalanced flora, and possible bacterial or fungal pathogens. This stool test can help reveal hidden causes behind acute or chronic conditions that develop from parasitic infection or dysbiosis.

Intestinal Permeability Assessment
The Intestinal Permeability Assessment is a powerful and noninvasive assessment of small intestinal absorption and barrier function in the bowel. The small intestine uniquely functions as a digestive/absorptive organ for nutrients as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, and other macromolecules. Both malabsorption and increased intestinal permeability are associated with chronic gastrointestinal imbalances as well as many systemic disorders.

Metabolic/ Cardiovascular

Lipid Peroxides Profile (TBARS)
Lipid peroxides are the products of chemical damage done by oxygen free radicals to the polyunsaturated fatty acids of cell membranes. This test is an assay of total thiobarbituric acid-reactive substances (TBARS) in serum using HPLC. The HPLC separation step isolates the TBARS from potential interfering compounds that can give false elevations in a simple colorimetric assay. The results provide a measure of total serum lipid peroxidation, an indicator of whole body free radical activity. High levels of lipid peroxides are associated with cancer, heart disease, stroke, and aging.

Lipoprotein Particle Fractionation Test
Cholesterol testing has historically been used as the standard indicator for cardiovascular disease classified as HDL (good) or LDL (bad). However, it is actually the lipoprotein particles that carry the cholesterol throughout the body, not necessarily the cholesterol within them, that are responsible for key steps in plaque production and the resulting development of cardiovascular disease. Measuring cholesterol alone does not provide the complete picture and can be misleading. Approximately 50 percent of people suffering from heart attacks have shown “normal” cholesterol numbers (NHLBI – The National Heart, Lung, and Blood Institute). Measuring the lipoprotein subgroups using the Lipoprotein Particle Fractionation Test is the only way to evaluate new risk factors, which is crucial for an accurate assessment of cardiovascular risk – according to the National Cholesterol Education Program (NCEP).

Toxicity / Detoxification

PCBs Profile
The Polychlorinated Biphenyls (PCBs) Profile can help identify which of the most toxic PCBs a patient has been exposed to, and the body burden of the patient. We look at the most commonly found PCBs, that have been documented to cause adverse health problems. Levels are given both in parts per million (PPM), and as lipid-adjusted amounts so the clinician can best estimate the total body burden of these compounds.

Porphyrins Profile
Porphyrins are proteins involved in the formation of heme measured in urine. Heme is essential for the proper function of many proteins including oxygen transport, energy production, and detoxification. Proper porphyrin production is essential for our body’s capacity to detoxify toxins. Porphyrins are particularly well suited for assessing heavy metal toxicity or organic chemical exposure. Chemical exposure and a heavy toxic burden can have physiological effects resulting in impaired metabolism and cellular function.

Toxic Metals Assessment
Urine element testing is primarily used to monitor levels of exposure to toxic metals such as aluminum, arsenic, cadmium, lead, and mercury. This test is used to evaluate total body burden of toxic elements, and can also be used as with a chelating agent to assessed body stores. Pre and post chelating challenged are recommended.

Volatile Solvents Profile
Overexposure or chronic exposure to volatile solvents damages the central nervous system and causes chemical-driven liver and kidney damage. Benzene, in particular, has a severe toxic effect on the hematological system and is a recognized human carcinogen. Other solvents contribute to atrophy of skeletal muscles, loss of coordination, vision problems, and depression of the central nervous system. The Volatile Solvents Profile can help identify a patient’s prolonged exposure to the most commonly found volatile solvents that have been shown to cause serious health problems.

Click HERE or contact the Kaizen Medical Inc. office at (604)300-0787 to discuss these testing options and obtain more information.